https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12705 2) appears to be the major determinant of CBF and the factors determining MVo₂ (mainly developed tension and contractile state) are, therefore, major determinants of CBF. The direct effects of autonomic excitation on CBF appear relatively minor, however; the vagus, sympathetic nerves and adrenal medullary hormones profoundly alter CBF indirectly through changes in MVo₂. In the eschaemic heart with atheromatous occlusion of large vessels there is a reduced capacity for autoregulation, and nutrient flow is more dependent on pressure gradient. Hypertension and valvular disorders are often associated with raised MVo₂ but associated abnormalities in pressure gradient and resistance to flow often hinder the supply of CBF needed to meet high demands.]]> Wed 24 Jul 2013 22:24:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29819 p = 0.017). All CTP core volume estimations showed robust correlation with DWI (Pearson p-value < 0.001). As core volume increased, CTP demonstrated increased deviation from DWI. At the critical cut-offs of 25 mL and 70 mL, relative CBF demonstrated the best agreement with DWI for infarct core compared to the other CTP-derived measures of infarct core. Conclusion: Our study demonstrates close approximation between multiple CTP-derived measures of infarct core and DWI infarct volume, Especially relative CBF.]]> Wed 11 Apr 2018 17:03:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17421 Sat 24 Mar 2018 08:01:37 AEDT ]]>